Kisii University has managed to expand its research base by collaborating with different organizations both locally and internationally. This is geared towards promoting research activities within the University. To this end, the University has established partnerships with the following institutions;

S/NO MEMORANDA OF UNDERSTANDING
1. Memorandum of understanding between Kisii University and University of Kansas Medical Centre, USA 
2. Memorandum of Understanding between Kisii University and Pentecostal Life University Malawi 
3. Memorandum of Understanding between Kisii University and Computer Aid International, UK
4. Memorandum of Understanding between Kisii University and Kenya National Library Service(KNLS)
5. Memorandum of Understanding between Kisii University and Kenya Marine Fisheries Research Institute(KMFRI)
6. Memorandum of Understanding between Kisii University and Books for Africa, USA
7. Memorandum of Understanding between Kisii University and Jingdezhen University, China
8. Memorandum of Understanding between Kisii University and Bowling Green State University, USA
9. Memorandum of Understanding Between Kisii University and Austin Peay State University, USA
10. Memorandum of Understanding between Kisii University and International Computer Driving License(Africa) 
11. Memorandum of understanding between Kisii University and Kenya Agricultural and Livestock Research Organization(KARLO)
12. Memorandum of Understanding between Kisii University and University of Minnesota, USA
13. Memorandum of Understanding between Kisii University and Semyung University, Korea
14. Memorandum of understanding between Kisii University and University of Cape Town, South Africa 
15. Memorandum of Understanding between International Youth Fellowship(IYF) and Kisii University
16. Memorandum of Understanding between Kisii University and Kantar Public, UK
17. Memorandum of understanding between Kisii University and Mogadishu University, Somalia
18. Memorandum of Understanding between Kisii University and Kenya National Commission on Human Rights